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$130 Million

Syros

PIPE

Placement Agent, July 2022

Syros Pharmaceuticals, Inc. (the “Company” or “Syros”) is a biopharmaceutical company focused on redefining the power of small molecules to control the expression of genes. Based on the Company’s unique ability to elucidate regulatory regions of the genome, the Company aims to develop product candidates to treat patients with diseases that have eluded other genomics-based approaches. Syros is advancing a robust clinical-stage pipeline, including: tamibarotene, a first-in-class oral selective RARα agonist in RARA-positive patients with higher-risk myelodysplastic syndrome and acute myeloid leukemia; SY-2101, a novel oral form of arsenic trioxide in patients with acute promyelocytic leukemia; and SY-5609, a highly selective and potent oral CDK7 inhibitor in patients with select solid tumors. Syros also has multiple preclinical and discovery programs in oncology and monogenic diseases.