Applied Therapeutics is a clinical-stage biopharmaceutical company developing a pipeline of novel product candidates against validated molecular targets in indications of high unmet medical need. The first molecular target of the Company’s product candidates is aldose reductase (AR), an enzyme implicated in multiple diseases. Applied Therapeutics’ most advanced product candidate, AT-001, is a novel ARI with peripheral nerve permeability for the treatment of diabetic cardiomyopathy (DbCM). The Company is also advancing several other ARI clinical candidates, including AT-007 and AT-003, for the treatment of galactosemia and diabetic retinopathy (DR), respectively.