$40 Million

22nd Century Group, Inc.

Sole Placement Agent, June 2021

Registered Direct

22nd Century Group, Inc. (“22nd Century” or the “Company”) is a leading plant biotechnology company focused on technologies that alter the level of nicotine in tobacco plants the level of cannabinoids in hemp/cannabis plants through genetic engineering, gene-editing and modern plant breeding. The Company’s primary mission in tobacco is to reduce the harm caused by smoking through its reduced nicotine content tobacco cigarettes. The Company’s primary mission in hemp/cannabis is to develop and commercialize proprietary hemp/cannabis plants with valuable cannabinoid profiles and desirable agronomic traits.